When you reach for naproxen, a nonsteroidal anti-inflammatory drug used to reduce pain, swelling, and fever. Also known as Aleve, it's one of the most common over-the-counter pain relievers in the U.S. But just because it’s easy to buy doesn’t mean it’s safe for everyone. Millions take it for headaches, back pain, or arthritis, but few know the hidden risks hiding in plain sight.
Naproxen belongs to a group called NSAIDs, a class of drugs that block enzymes causing inflammation and pain. But unlike acetaminophen, which mostly targets pain, NSAIDs like naproxen also affect your stomach lining and kidneys. That’s why long-term users often end up with stomach ulcers, open sores in the digestive tract caused by reduced protective mucus—sometimes without warning. Studies show people over 65 or those on blood thinners have up to a 4x higher risk. And it’s not just your gut: naproxen can raise blood pressure, worsen heart failure, and interact badly with antidepressants, diuretics, and even some asthma meds.
You might not realize how often naproxen shows up in combo pills—some cold remedies, muscle rubs, or even sleep aids. Taking it with another NSAID like ibuprofen? That’s a recipe for trouble. And if you’ve ever been told to avoid alcohol while on painkillers, this is why. The combination doesn’t just upset your stomach—it can cause serious internal bleeding. Even if you feel fine now, damage can build up slowly. That’s why your pharmacist asks if you’ve taken anything else. They’re not just being thorough—they’re trying to keep you out of the ER.
What you’ll find in the posts below isn’t just a list of articles. It’s a practical guide to how naproxen fits into real-life health decisions. You’ll see how it compares to other pain meds, what conditions it’s used for (and when it’s a bad idea), how it interacts with common drugs like levothyroxine or blood pressure pills, and what symptoms you should never ignore. Some posts even show how it’s tied to bigger issues—like liver disease, kidney stress, or emergency reactions in seniors. This isn’t theory. It’s what people actually deal with when they reach for that bottle.
Diclofenac is effective for pain and inflammation, but carries higher risks than alternatives like ibuprofen, naproxen, and topical gels. Learn which options are safer and just as effective for arthritis, joint pain, and more.
